In Easy365Manager, you configure the “Enable automatic replies” checkbox as well as “Schedule automatic replies” to control how automatic replies function for a mailbox.
Watch a quick video guide here.
You can quickly locate the setting by opening up properties for a user, selecting the Mailbox tab, and clicking on Delivery Options.
This opens up the following form, where you find “Enable automatic replies” and “Schedule automatic replies” in the Automatic replies section:

In Easy365Manager, the “Enable automatic replies” and “Schedule automatic replies” settings correspond to the ‘AutoReplyState’ parameter of the Set-MailboxAutoReplyConfiguration PowerShell command.
The PowerShell command “Set-MailboxAutoReplyConfiguration -AutoReplyState” manages automatic reply behavior:
Set-MailboxAutoReplyConfiguration -Identity lene.hau@azure.skrubbeltrang.com -AutoReplyState Enabled
When set to Enabled, automatic replies are active. The mailbox sends predefined responses to incoming emails. When set to Disabled, automatic replies are turned off, and no responses are sent. With Scheduled, automatic replies are active only during specified dates.
Enabling ensures immediate responses to incoming emails, informing senders about the recipient’s unavailability. Useful for vacations or business trips.
Disabling prevents automatic responses, which is ideal when not wanting any automated replies, ensuring no unnecessary messages are sent.
It’s surprising to note that the auto-reply configuration in the Exchange Admin Center lacks the scheduling option:

Scheduling, which is included with Easy365Manager, provides the help desk with the convenience of central management without having to use PowerShell.